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The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Selected by Audrey Noireterre

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Selected by Jessica Chevallier, Pierre Caron

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

B. van de Kooij, A. Schreuder, R.S. Pavani, et al.

Selected by Jennifer Ann Black

Actin nucleators safeguard replication forks by limiting nascent strand degradation

Jadwiga Nieminuszczy, Peter R. Martin, Ronan Broderick, et al.

Selected by Roberto Amadio

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis

Daniel Salas-Lloret, Néstor García-Rodríguez, Lisanne Giebel, et al.

Selected by Pierre Caron

Nuclear myosin VI maintains replication fork stability

Jie Shi, Kristine Hauschulte, Ivan Mikicic, et al.

Selected by Pierre Caron

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R. White, et al.

Selected by Sree Rama Chaitanya

ARID1A regulates R-loop associated DNA replication stress

Shuhe Tsai, Emily Yun-Chia Chang, Louis-Alexandre Fournier, et al.

Selected by Sree Rama Chaitanya

Single-molecule live cell imaging of the Smc5/6 DNA repair complex

Thomas J. Etheridge, Desiree Villahermosa, Anja Irmisch, et al.

Selected by Jennifer Ann Black

RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility

Anna-Sophia Briod, Galina Glousker, Joachim Lingner

Selected by Upasana Roy

fork-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing

Magali Hennion, Jean-Michel Arbona, Laurent Lacroix, et al.

Selected by Jennifer Ann Black

Mutational signatures are jointly shaped by DNA damage and repair

Nadezda V Volkova, Bettina Meier, Víctor González-Huici, et al.

Selected by Kerryn Elliott